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KLF1 transcription regulated by FLI1 controls erythroid differentiation. (A,B) The expression of (A) GATA1 and KLF1 (B) in shGATA1-2 cells as determined by RT-qPCR. (C,D) The expression of (C) KLF1 and (D) ERG in shLDB1-2 cells, as determined by RT-qPCR. (E) The intricate regulatory circuit of FLI1 and other transcription factors leading to erythroid and megakaryocytic differentiation in <t>erythroleukemia</t> <t>HEL</t> cells. Depicted model shows that FLI1 loss through activation of GATA1 induces erythroid differentiation. FLI1 loss suppresses GATA2 transcription, leading to reduce megakaryocytic differentiation. Loss of GATA1 and GATA2 activates ERG which in contrast to FLI1, blocks megakaryocytic differentiation. LDB1, through negative regulation by FLI1, plays a critical during erythroid or megakaryocytic differentiation. Dotted line shows indirect regulation. ***P<0.001. KLF1, KLF transcription factor 1; FLI1, friend leukemia integration 1; GATA, GATA binding protein; sh, short hairpin; RT-qPCR, reverse transcription-quantitative PCR; ERG, ETS transcription factor ERG; ETS, E26 transformation-specific; CD, cluster of differentiation.
Human Erythroleukemia Cell Lines Hel, supplied by ATCC, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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human erythroleukemia cell line hel 92 1 7  (ATCC)
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ATCC human erythroleukemia cell line hel 92 1 7
KLF1 transcription regulated by FLI1 controls erythroid differentiation. (A,B) The expression of (A) GATA1 and KLF1 (B) in shGATA1-2 cells as determined by RT-qPCR. (C,D) The expression of (C) KLF1 and (D) ERG in shLDB1-2 cells, as determined by RT-qPCR. (E) The intricate regulatory circuit of FLI1 and other transcription factors leading to erythroid and megakaryocytic differentiation in <t>erythroleukemia</t> <t>HEL</t> cells. Depicted model shows that FLI1 loss through activation of GATA1 induces erythroid differentiation. FLI1 loss suppresses GATA2 transcription, leading to reduce megakaryocytic differentiation. Loss of GATA1 and GATA2 activates ERG which in contrast to FLI1, blocks megakaryocytic differentiation. LDB1, through negative regulation by FLI1, plays a critical during erythroid or megakaryocytic differentiation. Dotted line shows indirect regulation. ***P<0.001. KLF1, KLF transcription factor 1; FLI1, friend leukemia integration 1; GATA, GATA binding protein; sh, short hairpin; RT-qPCR, reverse transcription-quantitative PCR; ERG, ETS transcription factor ERG; ETS, E26 transformation-specific; CD, cluster of differentiation.
Human Erythroleukemia Cell Line Hel 92 1 7, supplied by ATCC, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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KLF1 transcription regulated by FLI1 controls erythroid differentiation. (A,B) The expression of (A) GATA1 and KLF1 (B) in shGATA1-2 cells as determined by RT-qPCR. (C,D) The expression of (C) KLF1 and (D) ERG in shLDB1-2 cells, as determined by RT-qPCR. (E) The intricate regulatory circuit of FLI1 and other transcription factors leading to erythroid and megakaryocytic differentiation in erythroleukemia HEL cells. Depicted model shows that FLI1 loss through activation of GATA1 induces erythroid differentiation. FLI1 loss suppresses GATA2 transcription, leading to reduce megakaryocytic differentiation. Loss of GATA1 and GATA2 activates ERG which in contrast to FLI1, blocks megakaryocytic differentiation. LDB1, through negative regulation by FLI1, plays a critical during erythroid or megakaryocytic differentiation. Dotted line shows indirect regulation. ***P<0.001. KLF1, KLF transcription factor 1; FLI1, friend leukemia integration 1; GATA, GATA binding protein; sh, short hairpin; RT-qPCR, reverse transcription-quantitative PCR; ERG, ETS transcription factor ERG; ETS, E26 transformation-specific; CD, cluster of differentiation.

Journal: Molecular Medicine Reports

Article Title: An intricate regulatory circuit between FLI1 and GATA1/GATA2/LDB1/ERG dictates erythroid vs. megakaryocytic differentiation

doi: 10.3892/mmr.2024.13231

Figure Lengend Snippet: KLF1 transcription regulated by FLI1 controls erythroid differentiation. (A,B) The expression of (A) GATA1 and KLF1 (B) in shGATA1-2 cells as determined by RT-qPCR. (C,D) The expression of (C) KLF1 and (D) ERG in shLDB1-2 cells, as determined by RT-qPCR. (E) The intricate regulatory circuit of FLI1 and other transcription factors leading to erythroid and megakaryocytic differentiation in erythroleukemia HEL cells. Depicted model shows that FLI1 loss through activation of GATA1 induces erythroid differentiation. FLI1 loss suppresses GATA2 transcription, leading to reduce megakaryocytic differentiation. Loss of GATA1 and GATA2 activates ERG which in contrast to FLI1, blocks megakaryocytic differentiation. LDB1, through negative regulation by FLI1, plays a critical during erythroid or megakaryocytic differentiation. Dotted line shows indirect regulation. ***P<0.001. KLF1, KLF transcription factor 1; FLI1, friend leukemia integration 1; GATA, GATA binding protein; sh, short hairpin; RT-qPCR, reverse transcription-quantitative PCR; ERG, ETS transcription factor ERG; ETS, E26 transformation-specific; CD, cluster of differentiation.

Article Snippet: The human erythroleukemia cell lines HEL (cat. no. ATCC-TIB-180) and 293T (cat. no. ATCC-CRL3216) [a derivative of the 293T (cat. no. 293tsA1609neo) cell line (cat. no. ATCC CRL-11268)], were previously obtained from ATCC.

Techniques: Expressing, Quantitative RT-PCR, Activation Assay, Binding Assay, Reverse Transcription, Real-time Polymerase Chain Reaction, Transformation Assay